Chapter 8 · 15 min

Medicines, Drugs, and Brain Activity

Chapter 8 of How the Brain Works: Medicines, Drugs, and Brain Activity.

Watch the complete chapter ↗

Visual credits

10 sources

Sources and credits for imagery used in this film, including material incorporated into explanatory animations.

  • L-DOPA-from-xtal-view-1-3D-bs-17

    Ben Mills

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    L-DOPA ball-and-stick model — Ben Mills, public domain, via Wikimedia Commons.

  • Arvid Carlsson at the 2011 Göteborg Science Festival

    Vogler

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    Arvid Carlsson at the 2011 Göteborg Science Festival — Vogler, CC BY-SA 3.0, via Wikimedia Commons.

  • Oleh Hornykiewicz, 1985

    Renate Heldt

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    Oleh Hornykiewicz, 1985 — Renate Heldt, public domain, via Wikimedia Commons.

  • Carbidopa ball-and-stick

    MarinaVladivostok

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    Carbidopa ball-and-stick model — MarinaVladivostok, CC0, via Wikimedia Commons.

  • Medicationlevodopa

    Revion101

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    Kinson levodopa/carbidopa bottle — Revion101, CC BY-SA 4.0, via Wikimedia Commons.

  • Cueing-for-Levodopa-Induced-Dyskinesias-in-Parkinsons-Disease-Video 1

    Eva Schaeffer, Gerd Linke, Daniela Berg

    Schaeffer E, Linke G, Berg D (2016), Cueing for Levodopa-Induced Dyskinesias in Parkinson's Disease, Video S1, Frontiers in Neurology, DOI 10.3389/fneur.2016.00237, CC BY 4.0.

  • Propofol2021

    James Heilman, MD

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    Propofol vial — James Heilman, MD, CC BY-SA 4.0, via Wikimedia Commons.

  • Use of Ether for Anesthesia title QS:P1476,en:"Use of Ether for Anesthesia" label QS:Len,"Use of Ether for Anesthesia"

    Southworth & Hawes (American, active 1844 - 1862) – daguerreotypist (American) Details on Google Art Project

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    Southworth & Hawes, Use of Ether for Anesthesia, late spring 1847, public domain, via Wikimedia Commons/J. Paul Getty Museum Google Art Project.

  • GABAA receptor schematic

    Boghog2, based on Shao; transmembrane arrangement revised by Schneedrache

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    GABA-A receptor schematic — Boghog2, based on Shao; revision by Schneedrache. Public domain, via Wikimedia Commons.

  • BIS JPN

    ignis

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

    BIS monitor and sensor — ignis, CC BY-SA 3.0, via Wikimedia Commons.

Research references

Selected sources from the episode’s research and scientific figures.

  1. Original study, 2014, PMID 25073474 ↗
  2. NEJM 2019 original ↗
  3. Primary paper ↗
  4. Sinemet prescribing information, Clinical Pharmacology ↗
  5. Cilia's human comparison ↗
  6. Politis's human PET/intervention study ↗
  7. Correct original, Brain, DOI 10.1093/brain/awm082 ↗
  8. Original follow-up ↗
  9. Soileau et al., original trial ↗
  10. Original 2003 FASEB paper ↗
  11. Primary paper ↗
  12. Original paper, accessible author repository ↗
  13. Original main findings ↗
  14. Original synthesis ↗
  15. Original study in author repository ↗
  16. Baertsch et al., 2021, eLife 67523 ↗
  17. Bateman and Levitt's mouse pathway study ↗
  18. FDA record ↗
  19. ClinicalTrials.gov record NCT06944522 ↗
  20. dashboard ↗
  21. Original German paper record, DOI 10.1007/BF01485901 ↗
  22. Original report record ↗
  23. Original NEJM abstract ↗
  24. author-hosted PDF ↗
  25. author-hosted full paper ↗
  26. Early Operation Using Ether for Anesthesia ↗
  27. Commons item ↗
  28. Nobel lecture ↗
  29. Nobel copyright policy ↗
  30. The Dynamics of the Brain under Anesthesia ↗
  31. First lecture ↗
  32. Beckman talk ↗
  33. BrainMind talk ↗
  34. How to Prevent Sudden Off Episodes ↗
  35. ON OFF Evaluation for DBS ↗
  36. Serious Science Brown explainer ↗
  37. https://pmc.ncbi.nlm.nih.gov/articles/PMC3523833/): ↗
  38. NINDS ↗
  39. Original Brain Research study ↗
  40. Original study, 2002 ↗
  41. 1989 original ↗
  42. 2022 pharmacology review ↗
  43. Nutt et al., 1984 ↗
  44. Cui et al., original study ↗
  45. NINDS clinical overview ↗
  46. https://doi.org/10.1016/S0006-8993(00)02758-X ↗
  47. Nobel Assembly account ↗
  48. first-person historical account ↗
  49. Original NEJM record ↗
  50. Original record ↗
  51. publisher ↗
  52. PMID 25488030 ↗
  53. interview transcript ↗
  54. full text ↗
  55. Original population study ↗
  56. later population cohort ↗
  57. Original study ↗
  58. Original study ↗
  59. Primate follow-up ↗
  60. FDA original label ↗
  61. 12-person phase I Nature report ↗
  62. 36-month sponsor announcement ↗
  63. PMC3162622 ↗
  64. Orser et al., 1994 ↗
  65. Original study ↗
  66. Original computational study, 2010 ↗
  67. Original computational study, 2013 ↗
  68. PMC identity ↗
  69. Primary study, eLife 2021 ↗
  70. Primary Neuron paper ↗
  71. MacDonald et al., 1987 ↗
  72. 1991 mouse hippocampal-neuron study ↗
  73. Original 2016 study ↗
  74. FDA clinical review, regulatory history ↗
  75. Ketalar label ↗
  76. Rossman, PMID 23256274 ↗
  77. parallel publication ↗
  78. Cook et al., original audit analysis ↗
  79. MGH institutional historical document ↗
  80. study of Abbott's actual surgical records ↗
  81. catalogue record ↗
  82. Støier et al., 2023, JBC ↗
  83. Huang et al., 2005 ↗
  84. PDF reference ↗
  85. Bachmutsky's regional-deletion study ↗
  86. Matthes et al., 1996 ↗
  87. FDA primary regulatory review ↗
  88. Finn and Whistler, 2001, Neuron ↗
  89. Swingler et al., Frontiers in Neuroscience, DOI 10.3389/fnins.2025.1597922 ↗
  90. CDC dataset xkb8-kh2a ↗
  91. 13 May 2026 CDC release ↗
  92. Lee et al., 2013 ↗
  93. FDA summary review, dated 16 October 2024 ↗
  94. FDA approval record PDF ↗
  95. AbbVie UK SmPC on emc ↗
  96. FDA record ↗
  97. original FDA label ↗
  98. Sinemet supplement letter signed 19 March 2026 ↗
  99. BlueRock September 2025 first-treatment announcement ↗
  100. NeuroImage 311:121193, DOI 10.1016/j.neuroimage.2025.121193 ↗
  101. Bai et al., Cell Biology and Toxicology 42:78 ↗
  102. “Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia,” version 1, 12 June 2026 ↗
  103. “Local and interregional thalamocortical dynamics show temporally dissociable changes…” ↗

How this film was made

Created and editorially directed by Anders Lunde using a custom production system developed over six months. AI assists research, drafting, programming, and visual production; I review and edit the material and make the final editorial decisions. Narration uses text-to-speech. Visuals combine custom-built scientific animations, AI-generated reconstructions, and credited scientific imagery.

Generated reconstructions illustrate scientific interpretations. They are distinct from photographs, specimens, and measured data.

More about the creator and production →