Chapter 8 · 15 min
Medicines, Drugs, and Brain Activity
Chapter 8 of How the Brain Works: Medicines, Drugs, and Brain Activity.
Watch the complete chapter ↗Visual credits
10 sourcesSources and credits for imagery used in this film, including material incorporated into explanatory animations.
L-DOPA-from-xtal-view-1-3D-bs-17
Ben Mills
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
L-DOPA ball-and-stick model — Ben Mills, public domain, via Wikimedia Commons.
Arvid Carlsson at the 2011 Göteborg Science Festival
Vogler
View original source ↗Source licence: CC BY-SA 3.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Arvid Carlsson at the 2011 Göteborg Science Festival — Vogler, CC BY-SA 3.0, via Wikimedia Commons.
Oleh Hornykiewicz, 1985
Renate Heldt
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Oleh Hornykiewicz, 1985 — Renate Heldt, public domain, via Wikimedia Commons.
Carbidopa ball-and-stick
MarinaVladivostok
View original source ↗Source licence: CC0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Carbidopa ball-and-stick model — MarinaVladivostok, CC0, via Wikimedia Commons.
Medicationlevodopa
Revion101
View original source ↗Source licence: CC BY-SA 4.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Kinson levodopa/carbidopa bottle — Revion101, CC BY-SA 4.0, via Wikimedia Commons.
Cueing-for-Levodopa-Induced-Dyskinesias-in-Parkinsons-Disease-Video 1
Eva Schaeffer, Gerd Linke, Daniela Berg
View original source ↗Source licence: CC BY 4.0Schaeffer E, Linke G, Berg D (2016), Cueing for Levodopa-Induced Dyskinesias in Parkinson's Disease, Video S1, Frontiers in Neurology, DOI 10.3389/fneur.2016.00237, CC BY 4.0.
Propofol2021
James Heilman, MD
View original source ↗Source licence: CC BY-SA 4.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Propofol vial — James Heilman, MD, CC BY-SA 4.0, via Wikimedia Commons.
Use of Ether for Anesthesia title QS:P1476,en:"Use of Ether for Anesthesia" label QS:Len,"Use of Ether for Anesthesia"
Southworth & Hawes (American, active 1844 - 1862) – daguerreotypist (American) Details on Google Art Project
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Southworth & Hawes, Use of Ether for Anesthesia, late spring 1847, public domain, via Wikimedia Commons/J. Paul Getty Museum Google Art Project.
GABAA receptor schematic
Boghog2, based on Shao; transmembrane arrangement revised by Schneedrache
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
GABA-A receptor schematic — Boghog2, based on Shao; revision by Schneedrache. Public domain, via Wikimedia Commons.
BIS JPN
ignis
View original source ↗Source licence: CC BY-SA 3.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
BIS monitor and sensor — ignis, CC BY-SA 3.0, via Wikimedia Commons.
Research references
Selected sources from the episode’s research and scientific figures.
- Original study, 2014, PMID 25073474 ↗
- NEJM 2019 original ↗
- Primary paper ↗
- Sinemet prescribing information, Clinical Pharmacology ↗
- Cilia's human comparison ↗
- Politis's human PET/intervention study ↗
- Correct original, Brain, DOI 10.1093/brain/awm082 ↗
- Original follow-up ↗
- Soileau et al., original trial ↗
- Original 2003 FASEB paper ↗
- Primary paper ↗
- Original paper, accessible author repository ↗
- Original main findings ↗
- Original synthesis ↗
- Original study in author repository ↗
- Baertsch et al., 2021, eLife 67523 ↗
- Bateman and Levitt's mouse pathway study ↗
- FDA record ↗
- ClinicalTrials.gov record NCT06944522 ↗
- dashboard ↗
- Original German paper record, DOI 10.1007/BF01485901 ↗
- Original report record ↗
- Original NEJM abstract ↗
- author-hosted PDF ↗
- author-hosted full paper ↗
- Early Operation Using Ether for Anesthesia ↗
- Commons item ↗
- Nobel lecture ↗
- Nobel copyright policy ↗
- The Dynamics of the Brain under Anesthesia ↗
- First lecture ↗
- Beckman talk ↗
- BrainMind talk ↗
- How to Prevent Sudden Off Episodes ↗
- ON OFF Evaluation for DBS ↗
- Serious Science Brown explainer ↗
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3523833/): ↗
- NINDS ↗
- Original Brain Research study ↗
- Original study, 2002 ↗
- 1989 original ↗
- 2022 pharmacology review ↗
- Nutt et al., 1984 ↗
- Cui et al., original study ↗
- NINDS clinical overview ↗
- https://doi.org/10.1016/S0006-8993(00)02758-X ↗
- Nobel Assembly account ↗
- first-person historical account ↗
- Original NEJM record ↗
- Original record ↗
- publisher ↗
- PMID 25488030 ↗
- interview transcript ↗
- full text ↗
- Original population study ↗
- later population cohort ↗
- Original study ↗
- Original study ↗
- Primate follow-up ↗
- FDA original label ↗
- 12-person phase I Nature report ↗
- 36-month sponsor announcement ↗
- PMC3162622 ↗
- Orser et al., 1994 ↗
- Original study ↗
- Original computational study, 2010 ↗
- Original computational study, 2013 ↗
- PMC identity ↗
- Primary study, eLife 2021 ↗
- Primary Neuron paper ↗
- MacDonald et al., 1987 ↗
- 1991 mouse hippocampal-neuron study ↗
- Original 2016 study ↗
- FDA clinical review, regulatory history ↗
- Ketalar label ↗
- Rossman, PMID 23256274 ↗
- parallel publication ↗
- Cook et al., original audit analysis ↗
- MGH institutional historical document ↗
- study of Abbott's actual surgical records ↗
- catalogue record ↗
- Støier et al., 2023, JBC ↗
- Huang et al., 2005 ↗
- PDF reference ↗
- Bachmutsky's regional-deletion study ↗
- Matthes et al., 1996 ↗
- FDA primary regulatory review ↗
- Finn and Whistler, 2001, Neuron ↗
- Swingler et al., Frontiers in Neuroscience, DOI 10.3389/fnins.2025.1597922 ↗
- CDC dataset xkb8-kh2a ↗
- 13 May 2026 CDC release ↗
- Lee et al., 2013 ↗
- FDA summary review, dated 16 October 2024 ↗
- FDA approval record PDF ↗
- AbbVie UK SmPC on emc ↗
- FDA record ↗
- original FDA label ↗
- Sinemet supplement letter signed 19 March 2026 ↗
- BlueRock September 2025 first-treatment announcement ↗
- NeuroImage 311:121193, DOI 10.1016/j.neuroimage.2025.121193 ↗
- Bai et al., Cell Biology and Toxicology 42:78 ↗
- “Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia,” version 1, 12 June 2026 ↗
- “Local and interregional thalamocortical dynamics show temporally dissociable changes…” ↗
How this film was made
Created and editorially directed by Anders Lunde using a custom production system developed over six months. AI assists research, drafting, programming, and visual production; I review and edit the material and make the final editorial decisions. Narration uses text-to-speech. Visuals combine custom-built scientific animations, AI-generated reconstructions, and credited scientific imagery.
Generated reconstructions illustrate scientific interpretations. They are distinct from photographs, specimens, and measured data.
More about the creator and production →