Chapter 1 · 18 min
How We Learned to Look Inside
Chapter 1 of How the Brain Works: How We Learned to Look Inside.
How the Brain Works | Ch 1 Part 1/2: How We Learned to Look Inside ↗How the Brain Works | Ch 1 Part 2/2: How We Learned to Look Inside ↗Visual credits
28 sourcesSources and credits for imagery used in this film, including material incorporated into explanatory animations.
Journey of Sound to the Brain
NIH/NIDCD
Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
[Exposition universelle de Paris, 1900, et portraits de célébrités] / Collection Félix Potin
Pierre Petit; Collection Félix Potin / Gallica
View original source ↗Source licence: Public domainVue de la grande cour de l'hopital royal de Bicestre. 2, G.23130
Jacques Rigaud / Paris Musées, G.23130
View original source ↗Source licence: CC0Cerveau de Louis Victor Leborgne dit Tantan 2
Selbymay
View original source ↗Source licence: CC BY-SA 4.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Siemens Magnetom Aera MRI scanner
Ptrump16
View original source ↗Source licence: CC BY-SA 4.0Camillo Golgi
Photographer unknown; historical Nobel-era publication
View original source ↗Source licence: Public domainPyramidal hippocampal neuron 40x
MethoxyRoxy
View original source ↗Source licence: CC BY-SA 2.5Photographic portrait of Santiago-Ramon-Cajal M.D.
Wellcome Library, London / Wellcome Images; photographer unspecified
View original source ↗Source licence: CC BY 4.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
PurkinjeCell
Santiago Ramón y Cajal / Instituto Cajal, Madrid
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Golgi 1885 Plate XX
Camillo Golgi; lithography P. A. Dagheri
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Electron micrograph of neuromuscular junction (cross-section)
National Institute of Mental Health / SynapseWeb
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Apparatus used by Galvani
Wellcome Library, London / Wellcome Images
View original source ↗Source licence: CC BY 4.0Luigi Galvani Experiment
Luigi Galvani
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Galvani 1791 plate, Fig. 2 frog preparation — source crop
Luigi Galvani
View original source ↗Source licence: Public domainFigure or page excerpt cropped from the source publication.
Hermann von Helmholtz photographed in 1884
Julius Cornelius Schaarwächter
View original source ↗Source licence: Public domainHelmholtz pendulum, Berlin, Germany, 1895-1910
Wellcome Library, London / Wellcome Images; instrument maker Berliner Physikalische Werkstatten GmbH
View original source ↗Source licence: CC BY 4.0HansBerger Univ Jena
Unknown author Unknown author
View original source ↗Source licence: Public domain1st-eeg
Hans Berger, 1929 report, portion of Fig. 13
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Godfrey Hounsfield
Unknown author Unknown author
View original source ↗Source licence: Public domainRIMG0277
No machine-readable author provided. Gdh~commonswiki assumed (based on copyright claims).
View original source ↗Source licence: CC BY-SA 3.0Schematic illustration of CT scanner, extracted from Policy implications of the computed tomography (CT) scanner (1978)
Congress of the United States, Office of Technology Assessment :
View original source ↗Source licence: Public domainIncorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Calibration; MRI (5940427469)
National Institute of Standards and Technology
View original source ↗Source licence: Public domainFMRI BOLD activation in an emotional Stroop task
Shima Ovaysikia, Khalid A. Tahir, Jason L. Chan and Joseph F. X. DeSouza
View original source ↗Source licence: CC BY 2.5Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
E. Hitzig and G. Fritsch, Brain of a monkey, 19thC.
Wellcome Library, London / Wellcome Images; E. Hitzig and G. Fritsch source
View original source ↗Source licence: CC BY 4.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
Wilder Penfield
United States National Library of Medicine
View original source ↗Source licence: Public domainOptogenetics imetronic
Bd008
View original source ↗Source licence: CC BY-SA 4.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
One minute laser-fiber alignment procedure (for optogenetics)
Tom Davidson
View original source ↗Source licence: CC BY 3.0Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.
E.D. Adrian, UCL 1955/56.
Wellcome Library, London / Wellcome Images
View original source ↗Source licence: CC BY 4.0
Research references
Selected sources from the episode’s research and scientific figures.
- 10.1016/j.cub.2025.03.081 ↗
- *Some features of the submicroscopic morphology of synapses in frog and earthworm* (1955) ↗
- Adrian and Zotterman, Part II, *The response of a Single End-Organ*, 23 April 1926 ↗
- Poldrack 2006 ↗
- DOI: 10.1038/s41583-022-00583-8 ↗
- *Investigating the methodological foundation of lesion network mapping* ↗
- institutional page ↗
- f22yfh2y ↗
- *Beitrag zum Studium der Medulla Oblongata…*, work d7gjxsg6 ↗
- Legado Cajal ↗
- A Squid Giant Axon Imaged at the Marine Biological Laboratory ↗
- MBA, *Research in to the Squid Axon…*, Gilpin & Brown ↗
- McGill Osler Penfield archive ↗
- Science Museum's surviving scanner record, co134790 ↗
- OpenNeuro ds000114 v1.0.2 ↗
- MIT's Explained: Optogenetics, 3:52 ↗
- Stanford Medicine's Optogenetics Innovation Lab, 4:13 ↗
- publisher record ↗
- originating UCL account ↗
- NASA's sound-speed equation ↗
- NIDCD, How Do We Hear? ↗
- PNAS 1977, DOI 10.1073/pnas.74.6.2407 ↗
- Nature 1977 ↗
- Jewett and Williston 1971 ↗
- 2018 experiment ↗
- Plante-Hébert et al., 2021 ↗
- full-text route ↗
- Levinson and Torreira 2015 ↗
- Roberts et al. 2015 ↗
- 2000 human fMRI study ↗
- Basic Neurochemistry chapter, Characteristics of the Neuron ↗
- Purves, Nerve Cells ↗
- primary record ↗
- *Eighty-six billion and counting*, Brain 148 (2025), 689–691 ↗
- official NIH YouTube upload ↗
- *Mysterious Monsieur Leborgne*, 2013 ↗
- French ↗
- Christopher Green's English translation ↗
- 1861 Anthropological Society report ↗
- the archival re-examination of that meeting ↗
- disconnection reconstruction paper ↗
- DOI 10.1093/brain/awm042 ↗
- Berkeley-hosted PDF ↗
- Sorbonne institutional account ↗
- collection directory ↗
- University of Iowa's primary-book catalog ↗
- MIT Press publication record ↗
- https://colluniv.sorbonne-universite.fr/collections_medicales/ ↗
- his Nobel lecture ↗
- Cajal's 12 December 1906 lecture, *The Structure and Connexions of Neurons* ↗
- 2025 historical investigation ↗
- bibliographic historical record ↗
- Nobel institutional history ↗
- official award record ↗
- *The fine structure of neurons* (1955) ↗
- *Synapses in the central nervous system* (1956) ↗
- *The History of the Synapse* (2020), DOI 10.1002/ar.24392 ↗
- PubMed identity ↗
- UNESCO listing context ↗
- Public Domain Review ↗
- project account ↗
- project license statement ↗
- santiagoramonycajal.org ↗
- *Untersuchungen über thierische Elektricität*, volume 1 (1848) ↗
- institutional volume record ↗
- 1929 source record ↗
- *Brain* 57, 355–385 ↗
- MBL institutional history ↗
- *Of frogs and men: the origins of psychophysiological time experiments, 1850–1865* ↗
- Helmholtz Association scholarly volume ↗
- Part III, touch and pressure, 6 August 1926 ↗
- 1934 paper ↗
- 2024 archival account ↗
- *Action Potentials Recorded from Inside a Nerve Fibre* ↗
- giant-axon explainer ↗
- Apparatus L0011376 ↗
- https://www.youtube.com/watch?v=g2hysrWbuZs): ↗
- https://www.youtube.com/watch?v=dxbffhJWd7M): ↗
- https://wellcomecollection.org/works/f22yfh2y/items): ↗
- DOI and publisher ↗
- Hitzig bibliography with digitized editions ↗
- Wundt's physiological psychology, chapter 5 ↗
- Somatic motor and sensory representation in the cerebral cortex of man ↗
- McGill Osler Library's archival account, Newsletter 119 ↗
- Curot et al. 2017 ↗
- Nitsch and Stahnisch 2018 ↗
- Curot et al. 2020 ↗
- series descriptions ↗
- Wilder Graves Penfield, 2:54 ↗
- CTV News clip uploaded by McGill ↗
- Nobel 2003 scientific explanation ↗
- NIBIB nuclear medicine ↗
- Nobel institutional history ↗
- system description ↗
- clinical application ↗
- 1973 Nature paper ↗
- Nobel autobiographical account ↗
- ISMRM account of Ian Young ↗
- PNAS paper ↗
- earlier 1990 rodent report ↗
- PNAS 89:5675–5679 ↗
- PNAS 89:5951–5955 ↗
- Magnetic Resonance in Medicine 25:390–397 ↗
- Nature 412:150–157, DOI 10.1038/35084005 ↗
- Bennett, Baird, Miller and Wolford 2009 salmon poster ↗
- 2011 follow-up ↗
- dataset_description.json ↗
- the accompanying paper ↗
- HCP Young Adult S1200 ↗
- Siddiqi, Kording, Parvizi and Fox 2022, *Causal mapping of human brain function* ↗
- Nagel et al. 2003 ↗
- *Millisecond-timescale, genetically targeted optical control of neural activity* ↗
- Nagel et al. intact-worm study ↗
- Barker, Jalinous and Freeston, 1985 TMS ↗
- Benabid et al. 1987 ↗
- Armbruster et al. 2007 chemogenetics ↗
- Gomez et al. 2017 ↗
- Authors' data/code repository ↗
- Hodgkin and Huxley 1952 ↗
- EyeWire/Ed Boyden, 5:23 ↗
- jurvetson's Boyden recording, 2:38 ↗
- 4:17 ↗
- 2016 circuitry page ↗
- NIH BRAIN photo/video competition ↗
- NIH's copyright FAQ ↗
- BRAIN 2.0 report ↗
- DOI 10.1007/BF01738910 ↗
- Loewi Nobel lecture, 12 December 1936 ↗
- Dale's lecture on the same date ↗
- original digitized offprint at Wellcome, npfxxfjc ↗
- Nobel award record ↗
- original 1952 report record ↗
- Eccles's own Nobel lecture ↗
- 10.1353/pbm.1960.0006 ↗
How this film was made
Created and editorially directed by Anders Lunde using a custom production system developed over six months. AI assists research, drafting, programming, and visual production; I review and edit the material and make the final editorial decisions. Narration uses text-to-speech. Visuals combine custom-built scientific animations, AI-generated reconstructions, and credited scientific imagery.
Generated reconstructions illustrate scientific interpretations. They are distinct from photographs, specimens, and measured data.
More about the creator and production →