Chapter 1 · 18 min

How We Learned to Look Inside

Chapter 1 of How the Brain Works: How We Learned to Look Inside.

How the Brain Works | Ch 1 Part 1/2: How We Learned to Look Inside ↗How the Brain Works | Ch 1 Part 2/2: How We Learned to Look Inside ↗

Visual credits

28 sources

Sources and credits for imagery used in this film, including material incorporated into explanatory animations.

  • Journey of Sound to the Brain

    NIH/NIDCD

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • [Exposition universelle de Paris, 1900, et portraits de célébrités] / Collection Félix Potin

    Pierre Petit; Collection Félix Potin / Gallica

  • Vue de la grande cour de l'hopital royal de Bicestre. 2, G.23130

    Jacques Rigaud / Paris Musées, G.23130

  • Cerveau de Louis Victor Leborgne dit Tantan 2

    Selbymay

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • Siemens Magnetom Aera MRI scanner

    Ptrump16

  • Camillo Golgi

    Photographer unknown; historical Nobel-era publication

  • Pyramidal hippocampal neuron 40x

    MethoxyRoxy

  • Photographic portrait of Santiago-Ramon-Cajal M.D.

    Wellcome Library, London / Wellcome Images; photographer unspecified

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • PurkinjeCell

    Santiago Ramón y Cajal / Instituto Cajal, Madrid

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • Golgi 1885 Plate XX

    Camillo Golgi; lithography P. A. Dagheri

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • Electron micrograph of neuromuscular junction (cross-section)

    National Institute of Mental Health / SynapseWeb

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • Apparatus used by Galvani

    Wellcome Library, London / Wellcome Images

  • Luigi Galvani Experiment

    Luigi Galvani

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • Galvani 1791 plate, Fig. 2 frog preparation — source crop

    Luigi Galvani

    Figure or page excerpt cropped from the source publication.

  • Hermann von Helmholtz photographed in 1884

    Julius Cornelius Schaarwächter

  • Helmholtz pendulum, Berlin, Germany, 1895-1910

    Wellcome Library, London / Wellcome Images; instrument maker Berliner Physikalische Werkstatten GmbH

  • HansBerger Univ Jena

    Unknown author Unknown author

  • 1st-eeg

    Hans Berger, 1929 report, portion of Fig. 13

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • Godfrey Hounsfield

    Unknown author Unknown author

  • RIMG0277

    No machine-readable author provided. Gdh~commonswiki assumed (based on copyright claims).

  • Schematic illustration of CT scanner, extracted from Policy implications of the computed tomography (CT) scanner (1978)

    Congress of the United States, Office of Technology Assessment :

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • Calibration; MRI (5940427469)

    National Institute of Standards and Technology

  • FMRI BOLD activation in an emotional Stroop task

    Shima Ovaysikia, Khalid A. Tahir, Jason L. Chan and Joseph F. X. DeSouza

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • E. Hitzig and G. Fritsch, Brain of a monkey, 19thC.

    Wellcome Library, London / Wellcome Images; E. Hitzig and G. Fritsch source

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • Wilder Penfield

    United States National Library of Medicine

  • Optogenetics imetronic

    Bd008

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • One minute laser-fiber alignment procedure (for optogenetics)

    Tom Davidson

    Incorporated into an explanatory animation; presentation may include cropping, labels and overlays.

  • E.D. Adrian, UCL 1955/56.

    Wellcome Library, London / Wellcome Images

Research references

Selected sources from the episode’s research and scientific figures.

  1. 10.1016/j.cub.2025.03.081 ↗
  2. *Some features of the submicroscopic morphology of synapses in frog and earthworm* (1955) ↗
  3. Adrian and Zotterman, Part II, *The response of a Single End-Organ*, 23 April 1926 ↗
  4. Poldrack 2006 ↗
  5. DOI: 10.1038/s41583-022-00583-8 ↗
  6. *Investigating the methodological foundation of lesion network mapping* ↗
  7. institutional page ↗
  8. f22yfh2y ↗
  9. *Beitrag zum Studium der Medulla Oblongata…*, work d7gjxsg6 ↗
  10. Legado Cajal ↗
  11. A Squid Giant Axon Imaged at the Marine Biological Laboratory ↗
  12. MBA, *Research in to the Squid Axon…*, Gilpin & Brown ↗
  13. McGill Osler Penfield archive ↗
  14. Science Museum's surviving scanner record, co134790 ↗
  15. OpenNeuro ds000114 v1.0.2 ↗
  16. MIT's Explained: Optogenetics, 3:52 ↗
  17. Stanford Medicine's Optogenetics Innovation Lab, 4:13 ↗
  18. publisher record ↗
  19. originating UCL account ↗
  20. NASA's sound-speed equation ↗
  21. NIDCD, How Do We Hear? ↗
  22. PNAS 1977, DOI 10.1073/pnas.74.6.2407 ↗
  23. Nature 1977 ↗
  24. Jewett and Williston 1971 ↗
  25. 2018 experiment ↗
  26. Plante-Hébert et al., 2021 ↗
  27. full-text route ↗
  28. Levinson and Torreira 2015 ↗
  29. Roberts et al. 2015 ↗
  30. 2000 human fMRI study ↗
  31. Basic Neurochemistry chapter, Characteristics of the Neuron ↗
  32. Purves, Nerve Cells ↗
  33. primary record ↗
  34. *Eighty-six billion and counting*, Brain 148 (2025), 689–691 ↗
  35. official NIH YouTube upload ↗
  36. *Mysterious Monsieur Leborgne*, 2013 ↗
  37. French ↗
  38. Christopher Green's English translation ↗
  39. 1861 Anthropological Society report ↗
  40. the archival re-examination of that meeting ↗
  41. disconnection reconstruction paper ↗
  42. DOI 10.1093/brain/awm042 ↗
  43. Berkeley-hosted PDF ↗
  44. Sorbonne institutional account ↗
  45. collection directory ↗
  46. University of Iowa's primary-book catalog ↗
  47. MIT Press publication record ↗
  48. https://colluniv.sorbonne-universite.fr/collections_medicales/ ↗
  49. his Nobel lecture ↗
  50. Cajal's 12 December 1906 lecture, *The Structure and Connexions of Neurons* ↗
  51. 2025 historical investigation ↗
  52. bibliographic historical record ↗
  53. Nobel institutional history ↗
  54. official award record ↗
  55. *The fine structure of neurons* (1955) ↗
  56. *Synapses in the central nervous system* (1956) ↗
  57. *The History of the Synapse* (2020), DOI 10.1002/ar.24392 ↗
  58. PubMed identity ↗
  59. UNESCO listing context ↗
  60. Public Domain Review ↗
  61. project account ↗
  62. project license statement ↗
  63. santiagoramonycajal.org ↗
  64. *Untersuchungen über thierische Elektricität*, volume 1 (1848) ↗
  65. institutional volume record ↗
  66. 1929 source record ↗
  67. *Brain* 57, 355–385 ↗
  68. MBL institutional history ↗
  69. *Of frogs and men: the origins of psychophysiological time experiments, 1850–1865* ↗
  70. Helmholtz Association scholarly volume ↗
  71. Part III, touch and pressure, 6 August 1926 ↗
  72. 1934 paper ↗
  73. 2024 archival account ↗
  74. *Action Potentials Recorded from Inside a Nerve Fibre* ↗
  75. giant-axon explainer ↗
  76. Apparatus L0011376 ↗
  77. https://www.youtube.com/watch?v=g2hysrWbuZs): ↗
  78. https://www.youtube.com/watch?v=dxbffhJWd7M): ↗
  79. https://wellcomecollection.org/works/f22yfh2y/items): ↗
  80. DOI and publisher ↗
  81. Hitzig bibliography with digitized editions ↗
  82. Wundt's physiological psychology, chapter 5 ↗
  83. Somatic motor and sensory representation in the cerebral cortex of man ↗
  84. McGill Osler Library's archival account, Newsletter 119 ↗
  85. Curot et al. 2017 ↗
  86. Nitsch and Stahnisch 2018 ↗
  87. Curot et al. 2020 ↗
  88. series descriptions ↗
  89. Wilder Graves Penfield, 2:54 ↗
  90. CTV News clip uploaded by McGill ↗
  91. Nobel 2003 scientific explanation ↗
  92. NIBIB nuclear medicine ↗
  93. Nobel institutional history ↗
  94. system description ↗
  95. clinical application ↗
  96. 1973 Nature paper ↗
  97. Nobel autobiographical account ↗
  98. ISMRM account of Ian Young ↗
  99. PNAS paper ↗
  100. earlier 1990 rodent report ↗
  101. PNAS 89:5675–5679 ↗
  102. PNAS 89:5951–5955 ↗
  103. Magnetic Resonance in Medicine 25:390–397 ↗
  104. Nature 412:150–157, DOI 10.1038/35084005 ↗
  105. Bennett, Baird, Miller and Wolford 2009 salmon poster ↗
  106. 2011 follow-up ↗
  107. dataset_description.json ↗
  108. the accompanying paper ↗
  109. HCP Young Adult S1200 ↗
  110. Siddiqi, Kording, Parvizi and Fox 2022, *Causal mapping of human brain function* ↗
  111. Nagel et al. 2003 ↗
  112. *Millisecond-timescale, genetically targeted optical control of neural activity* ↗
  113. Nagel et al. intact-worm study ↗
  114. Barker, Jalinous and Freeston, 1985 TMS ↗
  115. Benabid et al. 1987 ↗
  116. Armbruster et al. 2007 chemogenetics ↗
  117. Gomez et al. 2017 ↗
  118. Authors' data/code repository ↗
  119. Hodgkin and Huxley 1952 ↗
  120. EyeWire/Ed Boyden, 5:23 ↗
  121. jurvetson's Boyden recording, 2:38 ↗
  122. 4:17 ↗
  123. 2016 circuitry page ↗
  124. NIH BRAIN photo/video competition ↗
  125. NIH's copyright FAQ ↗
  126. BRAIN 2.0 report ↗
  127. DOI 10.1007/BF01738910 ↗
  128. Loewi Nobel lecture, 12 December 1936 ↗
  129. Dale's lecture on the same date ↗
  130. original digitized offprint at Wellcome, npfxxfjc ↗
  131. Nobel award record ↗
  132. original 1952 report record ↗
  133. Eccles's own Nobel lecture ↗
  134. 10.1353/pbm.1960.0006 ↗

How this film was made

Created and editorially directed by Anders Lunde using a custom production system developed over six months. AI assists research, drafting, programming, and visual production; I review and edit the material and make the final editorial decisions. Narration uses text-to-speech. Visuals combine custom-built scientific animations, AI-generated reconstructions, and credited scientific imagery.

Generated reconstructions illustrate scientific interpretations. They are distinct from photographs, specimens, and measured data.

More about the creator and production →